This systematic review and meta-analysis aimed to compare the efficacy, safety, and immunogenicity of biosimilars and reference biologics (adalimumab, etanercept, infliximab) in the treatment of ankylosing spondylitis (AS)./r/nWe conducted a systematic search of four electronic databases through 6 […]

BackgroundChronic spinal pain (CSP) is a major global health challenge. Virtual reality-based training (VRBT) shows promise as a complementary intervention for exercise therapy (ET).ObjectiveThis review aimed to provide conclusive evidence on the effectiveness of ET with and without the […]

To determine benefits and adverse effects (AE) of oral muscle-relaxants (MR) (non-benzodiazepines) for acute (< 6 weeks) and chronic (> 12 weeks) primary LBP, administered alone or combined with analgesics/NSAIDs./r/nCENTRAL, MEDLINE, EMBASE, CINAHL were searched for pertinent […]

Definitive diagnosis of multiple sclerosis (MS) requires exclusion of other central nervous system (CNS) disorders sharing similar clinical, pathological and radiological features. In this review we discuss some relatively uncommon disorders with special emphasis on their differentiation from MS […]

Position changes in patients with thoracic spinal stab wounds may cause displacement of embedded sharp objects, increasing the risk of spinal cord or surrounding tissue injury. Management of these cases under anesthesia requires a carefully planned approach to minimize movement and ensure patient […]

The pain, compromised spinal biomechanics, and limited mobility caused by thoracic vertebral compression fractures present complex clinical challenges. Conventional treatments for this condition have limitations, necessitating innovative solutions. Peripheral nerve stimulation (PNS), which […]

Ventricular tachycardia storm (VTS/ES) is defined as the occurrence of three or more episodes of sustained ventricular tachycardia within a twenty-four-hour period, with or without a defibrillator. It has not been reported de novo in trauma patients. The literature indicates blunt cardiac injury as […]

Oropharyngeal perforation is extremely rare but dreaded. The majority of previous reported cases were iatrogenic. Till now, there is no report of traumatic oropharyngeal perforation secondary to a cervical fracture. We report a case of oropharyngeal perforation identified in anterior cervical […]

Although instrumented fusion is the most widely accepted surgical treatment for adolescent idiopathic scoliosis, it leads to permanent spinal motion loss and an increased risk of adjacent segment degeneration. Consequently, there is great interest in finding nonfusion methods to correct scoliosis […]

B3GALT6 -related disorders are characterized by severe early-onset spinal deformities requiring surgical corrections but are associated with increased risks of perioperative complications. This study reports the clinical experience and outcomes of selecting the substantially touched vertebra (STV) […]

Spondyloptosis (Grade-V spondylolisthesis) is the most severe form of spondylolisthesis and presents significant surgical challenges due to its rarity and complexity. This study aimed to outline the key aspects of posterior-only L5 partial spondylectomy and reduction of L4 onto S1 for […]

We aimed to assess differences in baseline characteristics, efficacy, and safety of advanced therapies between male and female patients with axial spondyloarthritis (axSpA) in randomized controlled trials (RCTs)./r/nWe conducted a systematic literature search for RCTs assessing the efficacy of […]

We compared the efficacy of romosozumab and denosumab in elderly women with primary osteoporosis and knee osteoarthritis in a randomized controlled trial. A total of 112 participants aged 75-90 years were randomized equally into the romosozumab and denosumab groups. Among these, 49 and 52 […]

To better investigate neurobiological heterogeneity in fibromyalgia for its symptom diversity and individual differences./r/nWe collected structural MRI data and clinical characteristics of Chinese female fibromyalgia patients and healthy controls matched by age and educational level, then invited […]

Percutaneous vertebroplasty (PVP) is a minimally invasive procedure frequently employed to treat osteoporotic vertebral compression fractures in the elderly. However, bone cement leakage is a complication that cannot be completely avoided of PVP, which may lead to disastrous consequences. We […]

This study focuses on the clinical management of lumbar degenerative diseases and employs meta-analysis methods to comprehensively investigate and compare the safety and pedicle screw placement accuracy of TiRobot-assisted technology versus freehand techniques in lumbar interbody fusion surgery. […]

Lumbar spondylolisthesis is a prevalent spinal disorder for which the primary treatment approach involves surgical intervention, including reduction, decompression, internal fixation, and bone graft fusion. This systematic review evaluated and compared the clinical efficacy of posterior lumbar […]

Spondyloarthritis (SpA) is a chronic inflammatory disease characterized by axial, peripheral, and extra-musculoskeletal manifestations. Axial involvement manifests as sacroiliitis, spondylitis, and peripheral involvement in the form of arthritis, enthesitis, and dactylitis. The […]

Paragangliomas are rare neuroendocrine tumors that can manifest with endocrinological symptoms from excessive catecholamine secretion and symptoms from mass effect depending on biochemical behavior and tumor location./r/nFollowing an encounter with a patient with a rare case of paraganglioma of the […]

Paragangliomas are rare neuroendocrine tumors that can manifest with endocrinological symptoms from excessive catecholamine secretion and symptoms from mass effect depending on biochemical behavior and tumor location./r/nFollowing an encounter with a patient with a rare case of paraganglioma of the […]

Scoliosis is a three-dimensional structural deformity of the spine that leads to restricted spinal motion, weakness in the paraspinal muscles, reduced cardiopulmonary function, and chronic physical and psychological pain. It also impacts patients' quality of life. According to statistics, as of […]

Spondylocostal dysplasia (SCD) is characterized by vertebral defects and rib abnormalities. Following radiological diagnosis, further genetic testing is conducted to confirm the mutant loci and identify the subtype of SCD. While seven loci potentially associated with SCD have been identified, rare […]

A healthy 15-year-old male athlete presented with upper thoracic congenital kyphoscoliosis, causing notable pain and limiting participation in competitive sports. In addition to mid and low back pain related to sagittal profile, the patient also expressed concerns regarding shape of his back from […]

This meta-analysis aims to explore the effects of resistance training on bone mineral density (BMD) in postmenopausal women, specifically focusing on different training intensities, durations, frequencies, and periods, across various skeletal sites lumbar spine (LS), femoral neck (FN), total hip […]

The optimal surgical techniques for cervical ossification of the posterior longitudinal ligament (OPLL) remain controversial due to insufficient high-level evidence. We investigated the following surgical approaches for cervical OPLL: anterior decompression and fusion (ADF), anterior cervical […]

Cervical spondylotic myelopathy (CSM) is a common cause of progressive neurological decline in elderly patients, often necessitating surgical decompression. Anterior cervical discectomy and fusion (ACDF) and anterior cervical corpectomy and fusion (ACCF) are commonly used procedures. However, there […]

AO Spine NA Webinar—Pediatric Deformity

Pathogenic variants of sacsin (SACS) gene cause autosomal recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS). It is a hereditary neurological disorder manifested with gait ataxia, intentional tremor, lower limb pyramidal signs and pes cavus. It was originally described in the late 1970s and […]

Anterior Lumbar Interbody Fusion (ALIF) is a commonly performed spine surgery procedure used to treat lumbar conditions such as degenerative disc disease, spondylolisthesis, and spinal deformities. Traditionally, it has been performed using open and mini-open surgical techniques. Recently, however, […]

AO Spine NA Webinar—Clinical Biomechanics in Spinal Surgery

Global Training for Neurosurgery Residents - Farhan Siddiq, MD; Michael Ortiz, MD; & Ravi Nunna, MD

Therapeutic Strategies for Mobile Spine Chordoma - Mario De Robertis, MD & Cristiana Griffoni, PhD

Researchers have uncovered a surprising new role for netrin1, a crucial protein in neural development, as a regulator that limits bone morphogenetic protein signaling in the developing spinal cord.

An international study has discovered that people living with the neurodegenerative condition spinal muscular atrophy (SMA) are at higher risk of developing fatty liver disease, suggesting that SMA patients may face additional health problems over time. This finding raises significant concerns […]

January 2023 In this month's update you will find the new export functionality that allows you to safely export your clinical cases directly from CaseFolio to your device. The post New in January: case export appeared first on myAO.

December 2022 You can now choose what you want to see on your myAO feed! In this month's update you will find a new feed design and experience divided into network activity and knowledge updates. The post New in December – A new feed experience appeared first on myAO.

Call for applications: AO Spine Education Commission Chairperson

Open call: AO Spine 2021 Research Start-up Grant