Osteoporosis is a common complication in patients with primary biliary cholangitis (PBC). This study aimed to compare the efficacy and safety of denosumab and zoledronic acid (ZOL) in treating osteoporosis in PBC patients./r/nThis multicenter, randomized, open-label trial enrolled Japanese patients […]

Prompt diagnosis and treatment of spinal tuberculosis are key in preventing its neurological and physical sequelae. This affection, also known as Pott's disease, should be considered a differential diagnosis in patients presenting with unexplained back pain that can lead to neurological symptoms […]

This international multicenter retrospective cohort study investigated predictors of relapse, acute attack severity, and six-month disability in patients with AQP4-IgG-positive NMOSD, MOGAD, and double-seronegative demyelinating syndromes./r/nWe analyzed 238 patients (132 NMOSD, 69 MOGAD, 37 […]

Solitary, benign retroperitoneal neurofibromas are exceedingly rare. Our case report highlights a man who presented with left-sided abdominal pain and left lower extremity numbness and weakness. On cross-sectional imaging, a 12.1 cm × 9.8 cm × 7.5 cm lobulated, well-marginated mass emanating […]

Currently three types of regional nerve blocks are commonly administered to provide analgesia to patients with hip fractures; the Fascia-Iliaca Compartment Block (FICB), Femoral Nerve Block (FNB) and Pericapsular Nerve Group Block (PENG). It is unclear which of these provides the best analgesia and […]

This case describes a woman in her 30s presenting with a 2 month history of thoracic pain, initially suspected to be costochondritis. The pain was unresponsive to conservative management, and imaging revealed a paravertebral mass at the T6-T7 level. The differential diagnosis included malignancy, […]

Research and clinical practice approaches to chronic low back pain (CLBP) have predominantly focused on biomedical and psychological aspects, often overlooking social influences. The biopsychosocial (BPS) model provides a theoretical framework for conceptualizing CLBP as the outcome of complex […]

: Ankylosing spondylitis (AS) is a chronic inflammatory disorder that causes progressive ossification and fusion of the spine, particularly in the cervical region. This results in a rigid spinal column that is highly susceptible to unstable fractures, even after low-energy trauma. Cervical […]

: Congenital scoliosis (CS) is a developmental disorder characterized by abnormal vertebral development during embryogenesis. Despite the identification of genes involved in vertebral development, the underlying genetic causes of CS remain largely unknown. Monozygotic (MZ) twins discordant for CS […]

Myogenic motor-evoked potentials (myogenic MEPs) and Direct waves (D-waves) are essential for monitoring motor pathways during intramedullary spinal cord tumor (IMSCT) resections. However, the diagnostic accuracy of alarm criteria and the prognostic value of reversible versus irreversible changes […]

Synthesised data on the global prevalence of scoliosis in children and adolescents and its associated risk factors remain scarce. This systematic review aimed to estimate the global prevalence of scoliosis in children and adolescents and identify associated risk factors in children and […]

An 86-year-old man underwent closed reduction and internal fixation of a comminuted intertrochanteric hip fracture with a cephalomedullary nail on a Hana table. Postoperatively, a displaced fracture subluxation of L1 was detected, resulting in complete loss of motor and sensory function below L1. […]

BackgroundAdolescent idiopathic scoliosis represents a complex three-dimensional spinal deformity of unknown etiology. It frequently results in visible deformities, decreased daily functional capacity, impaired pulmonary function, and psychological distress. Personalized treatment options for […]

A woman in her late 80s presented at midnight to the emergency department with sudden onset difficulty breathing, neck pain and neck swelling. There was no history of recent illness. Paramedics recorded saturations of 80% on air, improving to 96% with 15 L of oxygen via a non-rebreathe mask. CT […]

Cervical spine injuries in mixed martial arts athletes present unique challenges, especially regarding return to play after anterior cervical discectomy and fusion. While single-level anterior cervical discectomy and fusion has shown favorable return to play outcomes in collision sports, mixed […]

We report here a very rare case of a 54-year-old patient admitted for acute headache, vertigo and dizziness, 48 h after a sudden episode of transient low back pain. Noncontrast CT scan of the head and brain MRI showed several fat droplets with a distribution in the subarachnoid spaces, the lateral […]

The optimal surgical approach for managing multilevel cervical disc degeneration remains debatable, particularly regarding the comparative efficacy and safety of hybrid surgery (HS) versus anterior cervical discectomy and fusion (ACDF). This meta-analysis aimed to evaluate the efficacy and safety […]

Neurogenic claudication (NC) due to lumbar spinal stenosis is the most common reason for spinal surgery in older adults. Prehabilitation may improve outcomes and reduce costs, but current evidence is conflicting. It remains unclear who benefits most, which mechanisms optimise outcomes and what […]

Increases in lumbar spine BMD account for 30-41% of the vertebral fracture risk reduction with teriparatide treatment. The remaining fracture risk reduction is caused by improvements in non-BMD determinants of bone strength./r/nChanges in BMD account for a small percentage of the fracture risk […]

Obesity and the development of osteoporosis are closely related to abnormal visceral fat metabolism. The METS-VF is a novel body fat measurement method that integrates gender, waist circumference, and insulin resistance index. The purpose of this study was to look into the connection between […]

Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, has demonstrated 2-year efficacy in non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA (r-axSpA) phase III studies./r/nAssess the impact of BKZ on peripheral […]

Molybdenum 47.5 Rhenium Alloy Rods in Complex Spine Surgery - Stephen Enguidanos, M.D.

Veteran Response to Dosage in Chiropractic Therapy (VERDICT) was a pragmatic randomized trial testing chiropractic dosage effects in 766 veterans with chronic low back pain (CLBP) of ≥ 3 months. This cross-sectional analysis compares baseline characteristics of younger (18-to-64 years) and […]

Uniportal Interlaminar Approach: Approach and Progression Choke Points - Meng Huang, M.D.

Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare neurodegenerative disorder due to mutations in the SACS gene. While the typical phenotype is characterized by cerebellar ataxia, spasticity, and peripheral neuropathy, more reports are published of atypical and […]

Surgical fixation for occipitocervical instability can be challenging due to limitations in occipital instrumentation that include prominent hardware, limited fixation points on the occiput, and the risk of intracranial injury. Occipital instrumentation is particularly difficult in pediatric […]

Robot-assisted surgery (RAS) is increasingly used among younger patients. However, current literature often focuses on pairwise comparisons, which limits a comprehensive evaluation of robotic effectiveness across diverse conditions. This single-arm meta-analysis aimed to evaluate the effectiveness […]

For decades, researchers have worked to unravel the mysteries of post-traumatic epilepsy (PTE), a form of epilepsy that emerges after a traumatic brain injury (TBI). Now, a new study led by Texas A&M University neuroscientist Dr. Samba Reddy offers a sweeping view of how far the science has […]

Degenerative spinal diseases may lead to multisegmental instabilities and present as de novo scoliosis. Due to frequent primary and secondary complications, their treatment is controversial among spine surgeons. The aim of this systematic review is to investigate the postoperative quality of life […]

AO Spine NA Webinar— Managing Complications

Monozygotic 19-year-old female twins with Treacher Collins syndrome presented with progressive scoliosis; their primary thoracic curves measured 73° in Twin 1 and 52° in Twin 2. Both patients underwent posterior spinal fusion with low-density pedicle screw constructs and, at 1 year, demonstrated […]

A research collaboration involving scientists and students at The University of Texas at Dallas has found a clear connection between chronic sickle cell disease pain and the bacteria present in the gastrointestinal tract.

As a minimally invasive technique, Fu's subcutaneous needling (FSN) has been widely adopted in Chinese clinical practice for managing neck-type cervical spondylosis (CS). However, current evidence regarding its therapeutic efficacy remains inconclusive due to methodological limitations in existing […]

AO Spine NA Webinar—Pediatric Deformity

January 2023 In this month's update you will find the new export functionality that allows you to safely export your clinical cases directly from CaseFolio to your device. The post New in January: case export appeared first on myAO.

December 2022 You can now choose what you want to see on your myAO feed! In this month's update you will find a new feed design and experience divided into network activity and knowledge updates. The post New in December – A new feed experience appeared first on myAO.

Call for applications: AO Spine Education Commission Chairperson

Open call: AO Spine 2021 Research Start-up Grant