Severe postoperative complications after minimally invasive esophagectomy reduce the long-term prognosis of well-immunonutrition patients with locally advanced esophageal squamous cell carcinoma.
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While severe postoperative complications (SPCs) impact cancer prognosis, their effect on locally advanced esophageal squamous cell carcinoma (ESCC) patients with varying immunonutritional statuses after minimally invasive esophagectomy (MIE) is unclear./r/nThis retrospective study analyzed 442 patients with locally advanced ESCC who underwent MIE, investigating the relationship between SPCs and survival based on preoperative immunonutritional status, determined by the prognostic nutritional index (PNI). Nomograms were developed for patients with preserved immunonutritional status using Cox regression, and their performance was assessed./r/nOf the patients, 102 (23.1%) experienced SPCs after MIE. Five-year overall survival (OS) and disease-free survival (DFS) were significantly different between SPCs and non-SPCs groups ( < 0.001). In the preserved immunonutritional group, SPCs significantly reduced 5-year OS ( = 0.008) and DFS ( = 0.011), but not in the poor immunonutritional group (OS = 0.152, DFS = 0.098). Multivariate Cox regression identified SPCs as an independent risk factor for OS (HR = 1.653, = 0.013) and DFS (HR = 1.476, = 0.039). A nomogram for predicting OS and DFS in preserved immunonutritional patients demonstrated excellent performance./r/nSPCs significantly affect prognosis in ESCC patients with preserved immunonutritional status after MIE. Nomograms based on SPCs can predict OS and DFS in these patients.
