Perioperative Testosterone Supplementation Improves Outcomes of Orthopaedic Surgeries: A Systematic Review of Heterogeneous Studies.
Systematic Review
To assess the effect of perioperative testosterone supplementation on orthopaedic surgical outcomes./r/nThree online databases were searched from database inception until September 2024. Three reviewers independently screened all titles, abstracts, and full texts of articles investigating perioperative testosterone use in orthopaedic surgery. English-language studies, human studies, Level I or II randomized controlled trials, and studies examining testosterone supplementation given during the perioperative period of an orthopaedic surgery were included. Demographic data, surgical indications, details of testosterone use, and outcomes were recorded and analyzed./r/nIn total, 1,895 records were screened and 5 randomized controlled trials (4 Level I, 1 Level II) were included. One study evaluated patients undergoing elective total knee arthroplasty. One study investigated patients undergoing elective anterior cruciate ligament reconstruction. Three studies evaluated the effects of testosterone on patients undergoing hip fracture fixation. In total, 189 patients were included, with 84 receiving perioperative testosterone and 105 receiving placebo or a control intervention. One study showed length of stay was lower and ability to stand significantly improved in the testosterone group; 1 study revealed significant improvement in body composition and bone mineral density (BMD); 1 study showed testosterone and protein supplementation improved lean body mass, functional scores, and health-related quality-of-life scores; 1 study revealed perioperative testosterone supplementation increased lean mass postoperatively; and 1 short-term and underpowered study did not show significant improvement in the measured outcomes. The 5 studies showed heterogeneity in patient populations, procedure type, dosage, duration, testosterone therapy protocol, clinical outcomes, and follow-up duration./r/nAlthough evidence regarding orthopaedic perioperative use of testosterone replacement therapy is heterogeneous, 4 randomized controlled trials reviewed here found that testosterone supplementation improved clinical outcomes, body composition, and BMD. All 4 studies showed significant improvements in functional independence, BMD, muscle volume in the operative and nonoperative leg, Harris hip score, gait speed, Katz score, lean body mass, and strength./r/nLevel II, systematic review of Level I and II studies.
